Epimagnolin A

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Epimagnolin A 是从木兰花蕾中提取的木酚素，传统上在亚洲医学中用于治疗头痛和鼻塞。在之前的研究中，从M.fargesii中提取的一种草药化合物fargesin在人单核细胞THP-1细胞中发挥了抗炎作用。结果表明，epimagnolin A 可降低人单核 THP-1 细胞中佛波醇 12-肉豆蔻酸 13-乙酸酯 (PMA) 诱导的 IL-6 启动子活性和 IL-6 产生。

Epimagnolin A is a lignan obtained from the flower buds of Magnolia fargesii, which is traditionally used in Asian medicine for treating headache and nasal congestion.?A herbal compound fargesin obtained from M. fargesii, has exerted anti-inflammatory effects in human monocytic THP-1 cells in the previous study.?it was demonstrated that epimagnolin A reduced phorbol-12-myristate-13-acetate (PMA)-induced IL-6 promoter activity and IL-6 production in human monocytic THP-1 cells.?Furthermore, it was investigated the modulating effects of epimagnolin A on mitogen-activated protein kinase, nuclear factor-kappa B (NF-κB), and activator protein 1 (AP-1) activities.?Phosphorylation of p38 and nuclear translocation of p50 and c-Jun were down-regulated by epimagnolin A in the PMA-stimulated THP-1 cell.?The results revealed that epimagnolin A attenuated the binding affinity of NF-κB and AP-1 transcription factors to IL-6 promoter and IL-6 production through p38/NF-kB and AP-1 signaling pathways in the PMA-stimulated THP-1 cells.?These results suggest that epimagnolin A can be a useful drug for the treatment of inflammatory diseases.

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Others

Other Targets

Others

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41689-51-4

416.46

C23H28O7

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (240.12 mM)

COC1=C(OC)C(OC)=CC([C@H]2OC[C@]3([H])[C@@H](C4=CC=C(OC)C(OC)=C4)OC[C@@]32[H])=C1

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(-20℃)

With Ice Pack

≥ 2 years